Works are planned to replace the worn out carriageway on the A159 between Laughton and Brigg Road.
Work will start on Monday 12 October. The total programme of works is expected to last for seven weeks, subject to suitable weather.
As part of the works, a daytime road closure will be in place throughout the duration of the project from 8am to 5pm daily, Monday to Friday.
The diversion route for the closure will be via B1400, B1205, A159, and vice versa.
Cllr Clio Perraton-Williams, county councillor for Scotter Rural and executive support councillor for highways, said: "As part of these works, we'll be resurfacing a 4km stretch of the A159 between Laughton and Brigg Road. This is to replace road surface that is nearing the end of its serviceable life.
"We'll be doing everything we can to minimise disruption throughout the seven-week project, including maintaining access for residents, emergency services and buses.
"Once this project is finished, everyone traveling in and around the area should expect smoother and safer journeys."
For up-to-date information about this and other roadworks, visit www.lincolnshire.gov.uk/roadworks.